When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport. A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream. Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages. The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

For pure powder NMN sublingually, scoop the NMN into your mouth and hold it under your tongue. If you're taking a tablet, hold it under the tongue. If you're using a liposomal gel product, you can squeeze it into your mouth and hold under your tongue as well. Try to keep the products under your tongue for 30-45 seconds. If you swallow it sooner, the liposomes will still offer protection through the stomach and it will be absorbed through the intestine into your bloodstream.

When NAD is digested in the stomach, it then becomes NMN. NMN is digested to NR. Then NR to NAM. It is a misconception that NR or NMN survive digestion better. It is not possible. Research is now clear that orally, unprotected NAD+, NMN, and NR are almost entirely digested to NAM in digestive system. More bioavailable delivery methods like sublingual or liposomal are required to get more than 5% to the bloodstream. Once in the bloodstream, NAD+ has several pathways to enter the cells intact, or to be metabolized to NMN by the CD73 enzyme on the cell membranes. Thus, it restores intracellular NAD+ levels as effectively as NR and NMN. The advantage of NAD+ itself in the bloodstream is it is very stable. NR is quickly degraded to NAM in the blood. NMN is somewhere in the middle. Liposomal delivery protects all of these ingredients from degradation and digestion.